What is the connection between substance abuse and schizophrenia?

Dr. Nimisha H Nair
Written & Medically Reviewed By
Dr. Nimisha H Nair
Published on: 08 Nov 2024 | Last Updated on: 05 Oct 2026
connection between substance abuse and schizophrenia

A serious mental condition called schizophrenia impacts a person's actions, thoughts, and emotions. It significantly impairs at least one person's key life domains, such as self-care, interpersonal connections, and employment.

According to Jagruti Rehab Centre the schizophrenia symptoms often appear between the ages of 16 and 30 and are more prevalent in men than women.

Why Can Physical Activity Boost Our Mental Health?

Although studies have indicated that drug abuse raises the likelihood of getting schizophrenia or a comparable disorder, drugs do not directly cause schizophrenia. It would help if you emphasised that some medications, such as amphetamines, might have transient adverse effects which resemble schizophrenia.

A person's altered neurological function may occur when they take drugs over an extended period, a condition called addiction. Your dopamine systems may become overactive due to these lasting effects, which are comparable to some symptoms of schizophrenia. Drugs do not cause schizophrenia, but long-term drug use can also have effects like schizophrenia and drug abuse.

What are Substance Abuse and Schizophrenia?

Substance abuse refers to the chronic use of drugs or alcohol in a way that negatively impacts a person's physical or mental health, social functioning, and overall well-being. Substance abuse can lead to addiction, characterised by compulsive drug-seeking behaviour despite the negative consequences.

Schizophrenia, on the other hand, is a serious and persistent mental illness which impairs a person's ability to think, feel and behave clearly. Hallucinations, delusions, strange behaviour, and distorted thinking are common in people with schizophrenia.

Schizophrenia can profoundly impact a person's daily life and often requires long-term treatment with medication and therapy. [1]

How Does Substance Abuse Affect Schizophrenia?

As per the Jagruti Rehab Centre the use of drugs or alcohol can worsen the symptoms of schizophrenia and increase the risk of relapse. In some cases, substance abuse in patients with schizophrenia can even trigger the onset of schizophrenia in people predisposed to the disorder.

Therefore, individuals with schizophrenia need to avoid substance abuse and seek treatment if they have problems with addiction.

Relation Between Substance Abuse and Schizophrenia

Research suggests that substance abuse and schizophrenia are linked in several ways. First, substance abuse may increase the risk of developing schizophrenia, particularly among individuals with a genetic vulnerability. [2]

Addiction to drugs or alcohol can sometimes make schizophrenia symptoms worse, making treatment more challenging. [3]

Second, individuals with schizophrenia may be more likely to use drugs or alcohol to self-medicate or cope with the disorder's symptoms. For example, some individuals with schizophrenia may use drugs or alcohol to alleviate the negative symptoms of the disorder, such as apathy or social withdrawal.

Ultimately, the consequences of schizophrenia and substance addiction on the brain may coincide. Both conditions can affect the neurotransmitters in the brain, leading to changes in brain chemistry and function. This can make it more difficult to treat both conditions effectively, as a treatment for one condition may affect the other.

Overall, the relationship between substance abuse and schizophrenia is complex and multifaceted. Both disorders must be treated comprehensively in tandem for patients who have either illness.

How We Treat Schizophrenia?

Treating substance abuse and schizophrenia can be challenging as these are complex disorders that can significantly impact an individual's mental and physical health. However, with proper treatment and support, individuals can recover from these disorders and improve their quality of life.

  • At our mental hospital in Mumbai, treatment for schizophrenia and substance abuse often involves a combination of medication and therapy.
  • Cognitive-behavioural therapy (CBT) and motivational interviewing are two common forms of therapy used to treat substance abuse.
  • Antipsychotic medications can effectively reduce symptoms such as hallucinations and delusions, while therapy can help individuals learn to manage their symptoms and improve their functioning.
  • It is important to note that substance abuse treatment and schizophrenia can be complex and may require ongoing support.

    Frequently Asked Questions

    While studies have indicated that drug abuse raises the likelihood of getting schizophrenia or a comparable disorder, drugs do not directly cause schizophrenia. You should emphasise that some medications, such as amphetamines, might have transient adverse effects which resemble schizophrenia.

    Among those who are vulnerable, some drugs, particularly cannabis, cocaine, LSD, or amphetamines, may cause schizophrenia-related symptoms. [4] Cocaine or amphetamine usage can result in psychosis, and those recovering from an earlier episode may revert.

    Alcohol, tobacco, cannabis, and cocaine use issues are substantially more common among people having schizophrenia compared to the general population. According to one study, 47% of others with schizophrenia reported having problems with drug or alcohol misuse, compared to 16% of those without serious psychiatric disease.

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    Dr. Nimisha H Nair
    Written & Medically Reviewed By

    Dr. Nimisha H Nair

    Medically reviewed by: Dr. Nimisha H Nair, (MBBS, DPM Psychiatry), Consultant Psychiatrist at Jagruti's Malad Centre, with over 7 years of experience treating psychiatric disorders, addiction, and dementia. She is also affiliated with Raha for child and adolescent care, and provides caregiver counseling. (Reg. No: 2017051827).

    References

    Last Updated: 05 Oct 2026

    [1] World Health Organization. Schizophrenia [Fact sheet]. 11 September 2026. Available from: https://www.who.int/news-room/fact-sheets/detail/schizophrenia

    [2] Lähteenvuo M, Batalla A, Luykx JJ, Mittendorfer-Rutz E, Tanskanen A, Tiihonen J, Taipale H. Morbidity and mortality in schizophrenia with comorbid substance use disorders. Acta Psychiatrica Scandinavica. 2021;144(1):42–49. doi:10.1111/acps.13291. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8359349/

    [3] National Institute on Drug Abuse. Co-Occurring Disorders and Health Conditions. Available from: https://nida.nih.gov/research-topics/co-occurring-disorders-health-conditions

    [4] NHS. Causes – Schizophrenia. Page last reviewed 13 April 2023. Available from: https://www.nhs.uk/mental-health/conditions/schizophrenia/causes/

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