Mental Health

Is ADHD Genetic? What the Science Says and Why It Matters

Written By

Dr. Amar Shinde

Published on: 20 Jun 2025 | Last Updated on: 25 Jun 2025

Have you ever thought about whether persistently restless behaviour or difficulty concentrating might be something embedded in your DNA? Is ADHD genetic, or is it merely environmental? You are in good company. According to research, ADHD can impact up to 5–7% of children, and for many (about two-thirds of cases), the symptoms can continue into adulthood. 

But what is behind the complicated condition? What scientists know about the genetic origins of ADHD, examine the environmental factors that contribute, and consider why this matters for families who are looking for help.

What Is ADHD From? Is It Hereditary?

ADHD (Attention‑Deficit/Hyperactivity Disorder) is a neurodevelopmental disorder characterised by inattention, impulsivity, and hyperactivity. Environmental variables influence this condition, but the contribution to ADHD has a large genetic component. Estimates of heritability for ADHD using twin and family studies have cited numbers between 74% and 80%. This indicates that genetics accounts for a range of 74–80% of the differences we see between people. 

This is substantially higher than almost all psychiatric conditions for which heritability estimates are available. If one of your first-degree relatives (sibling or child) has ADHD, then your estimated risk for ADHD is now 4–10 times greater than the general population medlineplus.gov. So, does genetic factor cause ADHD? Absolutely, yes—genes also significantly estimate risk for ADHD.

Related Learning: ADHD Case Study

Is ADHD Genetic?

Yes, ADHD is highly heritable genetically, but it’s not like a simple hereditary trait; it’s polygenic. You have many genes contributing to the cause of ADHD, each one with a small contributing effect. Genome-wide studies suggest that only about 22% of the heritability of ADHD can be traced using common genetic variants, while dozens or even thousands of rare genetic variants are also contributing to ADHD heritability. 

It is important to realise that a complete genetic test will not find all of those contributing variants. This is the missing heritability problem. Regardless, the bottom line is that genetic causes of ADHD play a very important role, even if it is too early to trace all the genes involved.

What Parts of the Brain Are Affected by ADHD?

ADHD influences how brain systems responsible for attention, impulse control, and emotions operate. Brain areas affected by ADHD are:

• Prefrontal cortex: reduced activation leading to diminished executive function and focus
• Basal ganglia, cerebellum, limbic system: disruptions lead to hyperactivity and emotional regulation
• Chemical imbalances: decreased dopamine and norepinephrine, which are important for concentration

Personalised genetic variations in genes such as DRD4, DAT1, COMT, and others that contribute to how brain chemicals are regulated

How Does ADHD Impact the Brain?

Neurologically, ADHD is characterised by:

• Delayed brain development in critical regions 
• Reduced brain volume in reward and emotion centres 
• Reduced connectivity strength in areas supporting self-control and planning 

These neural differences correlate with normative ADHD behaviours, and other genetic research reveals inherited risk associated with brain structure.

Does Genetics Cause ADHD and What About the Environment?

Are toxins and pollution the cause of ADHD? Not by themselves, but they matter. Environmental insults like prenatal lead exposure, maternal smoking, or complications from childbirth account for around 20–30% risk. There are also gene–environment interactions, e.g., prenatal smoking amplified the effects of the DRD4 gene.

Do nutritional factors contribute to ADHD? Too much sugar or too much screen time do not cause ADHD, but deficits in omega‑3s, iron, zinc, and magnesium can exacerbate symptoms. Remediating these nutritional deficits can help, but no substitute for treatment.

How Does Culture Influence ADHD?

Cultural beliefs impact the manifestation of ADHD or the diagnosis. For example:

• In some areas, hyperactivity translates into "just kids being kids"
• In structured school systems, it might present differently

So, is ADHD genetic? Yes, but culture impacts the recognition and treatment of it.

How Do Genetic and Environmental Factors Interact in ADHD?

While genes are important, they do not operate alone. Environmental influences can interact with genetic vulnerabilities to influence the likelihood and/or severity of ADHD. This interaction is called gene-environment interaction. 

As an illustration, consider a child who inherits a genetic vulnerability towards ADHD. If, along that child's pregnancy and early development, they are exposed to lead, prenatal stress, premature birth, and so on, the chance that the child will develop symptoms of ADHD may increase. Similarly, if a child is exposed to the influences of smoking or drinking during pregnancy, alongside inherited vulnerability, the effects can amplify. 

Researchers suggest that studying both genes as causes of ADHD and environmental risk factors should improve treatment options by informing the development of more individualised treatment plans for children with ADHD. Additionally, this dual approach of using genetic and environmental influences holds promise for preventative measures like improved prenatal healthcare or offering behavioural support for at-risk children as soon as they can come through the door.

Why Choose Jagruti Rehab for Addiction & ADHD Support

At Jagruti Rehab, we understand that ADHD is often biologically driven, but we also know that environment, nutrition, and culture are a big part of each ADHD journey. This is why our dedicated psychiatrists, therapists, and nutritionists offer holistic, personalised care, founded on genetic evidence, and reinforce these discoveries with holistic support.

If you are looking for help with ADHD, whether you are doing this on your own or with an addiction, we can help develop a fully individualised ADHD treatment plan, positive energy therapy, and a fully advisory community fully invested in your success.

Get expert and holistic support for addiction and ADHD at Jagruti Rehab and start your journey to healing today.

Dr. Amar Shinde

Dr. Amar Shinde, founder of Jagruti Rehab, is a renowned psychiatrist in India with over two decades of experience in mental health, addiction recovery, and neuropsychiatry, dedicated to holistic, compassionate patient care.